"I was talking to Jennifer Aniston," David Fincher explains on the film's DVD commentary track. "We were talking about movies, and actors that she had worked with that she just loved, and Jake Gyllenhaal was one of them, and Mark Ruffalo was the other one." When it came time to finally start casting "Zodiac," Fincher remembered Aniston's glowing endorsements and wound up selecting both actors for the leading roles. "She was telling me just how unbelievably talented these guys were," Fincher added. He was especially interested in Gyllenhaal because he was a fan of "Donnie Darko." Both choices wound up being right on the money, as "Zodiac" has gone down as one of the best films of Fincher's career.
原来詹妮弗向大卫芬奇推荐了杰克吉伦哈尔和马克，说两位太棒了，如何如何杰出
导演选角的时候想起来这段话，最终决定选择这两名演员主演《十二宫》。